Nock, V.Muller, Y.Sellier, M.Verdier, C.2015-11-262015-11-262013Nock, V., Muller, Y., Sellier, M., Verdier, C. (2013) Biochemical Sensing Assays based on Coalescence-induced Self-propulsion Digital Microfluidics. Wellington, New Zealand: 7th International Conference on Sensing Technology (ICST 2013), 3-5 Dec 2013. in press.http://hdl.handle.net/10092/11427“© © 2013 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.”This work reports on coalescence-induced selfpropulsion as a driving mechanism to actuate microfluidic droplet assays. We demonstrate multi-droplet translation and assay-type sensing on a digital microfluidics platform by use of surface tension gradients alone. These gradients arise during the coalescence of two droplets of liquid having different compositions and therefore surface tensions. We demonstrate a chemiluminescence blood-detection reaction based on the mixing of two carrier droplets containing solutions of synthetic blood and luminol sensor solution. Presence of iron in the blood solution is recorded using digital imaging and analyzed via offline image processing. The results demonstrate the capability of the propulsion mechanism to propel droplets over several millimeters, thus enabling one to design a new family of chip-based biochemical sensor assays.enMicrofluidicssensor assaychemiluminescenceluminolimage processingConference Contributions - PublishedField of Research::09 - Engineering::0903 - Biomedical EngineeringField of Research::09 - Engineering::0906 - Electrical and Electronic EngineeringFields of Research::40 - Engineering::4003 - Biomedical engineering::400303 - Biomechanical engineeringhttps://doi.org/10.1109/ICSensT.2013.6727618