Starfinger, C.Chase, GeoffHann, C.E.Shaw, GeoffLambermont, B.Ghuysen, A.Kolh, P.Dauby, P.C.Desaive, T.2009-03-292009-03-292008Starfinger, C., Chase, J.G., Hann, C.E., Shaw, G.M., Lambermont, B., Ghuysen, A., Kolh, P., Dauby, P.C., Desaive, T. (2008) Model-based identification and diagnosis of a porcine model of induced endotoxic shock with hemofiltration. Mathematical Biosciences, 216(2), pp. 132-139.0018-9294http://hdl.handle.net/10092/2243A previously validated cardiovascular system (CVS) model and parameter identification method for cardiac and circulatory disease states are extended and further validated in a porcine model (N = 6) of induced endotoxic shock with hemofiltration. Errors for the identified model are within 10% when the model is re-simulated and compared to the clinical data. All identified parameter trends over time in the experiments match clinically expected changes both individually and over the cohort. This work represents a further clinical validation of these model-based cardiovascular diagnosis and therapy guidance methods for use with monitoring endotoxic disease states.enCardiovascular systemCardiac modelParameter identificationIntegral methodEndotoxinHemofiltrationSeptic shockJournal ArticleFields of Research::290000 Engineering and Technology::291500 Biomedical EngineeringFields of Research::320000 Medical and Health Sciences::329900 Other Medical and Health Sciences::329902 Medical biotechnologyhttps://doi.org/10.1016/j.mbs.2008.08.014