Hann, C.E.Chase, GeoffDesaive, T.Lambermont, B.Ghuysen, A.Kolh, P.Shaw, Geoff2010-04-202010-04-202009Hann, C.E., Chase, J.G., Desaive, T., Lambermont, B., Ghuysen, A., Kolh, P., Shaw, G.M. (2009) Model-based therapeutics for the Cardiovascular System - a Clinical Focus. Aalborg, Denmark: 7th IFAC Symposium on Modeling and Control in Biomedical Systems (MCBMS09), 12-14 Aug 2009.http://hdl.handle.net/10092/37836-pages (invited)This paper focuses on clinical results of a model-based cardiac diagnosis and therapy methodology. The method allows for accurate patient specific identification and prediction of a broad range of hemodynamics typical in the critically ill. Extensive porcine experiments have been performed involving drug induced pulmonary embolism and septic shock including hemofiltration therapy. The model-based methods consistently capture all measured cardiac variables, within 5-10% error throughout the experiments. Importantly, all the physiologically expected responses to pulmonary embolism and septic shock are captured and compare well to more directly measured but highly invasive procedures. The cardiovascular system model only requires clinical data that is readily available in the Intensive Care Unit. Therefore, the results demonstrate the potential for longer term developing a cardiac diagnosis and therapeutic guidance system for use in critical care at the bedside.enConference Contributions - OtherFields of Research::320000 Medical and Health Sciences::321000 Clinical Sciences::321003 Cardiology (incl. cardiovascular disease)Fields of Research::320000 Medical and Health Sciences::321000 Clinical Sciences::321009 Intensive careFields of Research::290000 Engineering and Technology::291500 Biomedical Engineering::291504 Biomechanical engineeringFields of Research::290000 Engineering and Technology::290900 Electrical and Electronic Engineering::290901 Electrical engineering