Onal, SevgiAlkaisi, MaanNock, Volker2021-05-272021-05-272019Onal S, Alkaisi MM, Nock V (2019). A microfluidic platform for applying localized and dynamically-controlled compression on cancer cells. 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019. 640-641.9781733419000https://hdl.handle.net/10092/101947In this work we report a microfluidic cell-culture platform with an integrated, actively-modulated actuator for the application of compressive forces on cancer cells. We show fabrication of the platform, mechanical characterization of the actuator and observed mechanotactic behavior of a monolayer of SKOV-3 ovarian cancer cells under static conditions. We further show compression and lysing of the cells, demonstrating suitability for mechanical stimulation with various pressures to study compressive forces in cancer microenvironments.enAll rights reserved unless otherwise statedMicrofluidicsMicro-pistonLocalized and controlled compressionCancer cellsConference Contributions - Published2021-03-30Fields of Research::32 - Biomedical and clinical sciences::3211 - Oncology and carcinogenesis::321101 - Cancer cell biologyFields of Research::40 - Engineering::4012 - Fluid mechanics and thermal engineering::401203 - Biomedical fluid mechanicsFields of Research::40 - Engineering::4003 - Biomedical engineering::400303 - Biomechanical engineering