Shearman, J.Micklewright, D.Hardcastle, J.Hamlin, M.Draper, N.2013-05-272013-05-272010Shearman, J., Micklewright, D., Hardcastle, J., Hamlin, M., Draper, N. (2010) The effect of physical activity on serum lipids, lipoprotein, and apolipoproteins. Archives of Exercise in Health and Disease, 1(2), pp. 43-49.1647-1652http://hdl.handle.net/10092/7763Objective: The aim of this study was to measure apolipoprotein-A1 and apolipoprotein-B serum concentrations during a physical activity program. Serum apolipoprotein concentrations may be a more sensitive indicator of coronary heart disease (CHD) risk than total cholesterol, triglycerides, low density lipoproteins and high density lipoproteins. Design: Thirty-seven sedentary, healthy adult males were randomly allocated to an exercise group (n=20) who underwent 12 weeks of aerobic physical activity or a sedentary group (n=17) who acted as nonexercising controls. Results: The exercise group increased their aerobic capacity (from 33±4 mL•kg-1•min-1 to 40±4 mL•kg-1•min-1) but the sedentary group did not. The percentage of body fat decreased in the exercise group (from 21.8% to 19.5%) but remained unchanged in the sedentary group. Serum cholesterol, lipoprotein and apolipoprotein concentrations did not change but serum triglyceride concentrations were reduced in the exercise group (from 1.8±1.3 mmol•L-1 to 1.2±0.4 mmol•L-1, p<0.05). The Apo-A1:Apo-B ratio increased in the exercise group (from 1.17±0.22 to 1.±0.27, p<0.05) but not in the sedentary group. Conclusion: Apolipoprotein concentrations in sedentary males are no more sensitive than other serum lipid concentrations but are appropriate for monitoring CHD risk-factor change during short-term light exercise interventions.enphysical activityserum lipidsapolipoproteinsJournal ArticleFields of Research::32 - Biomedical and clinical sciences::3205 - Medical biochemistry and metabolomics::320504 - Medical biochemistry - lipidsFields of Research::42 - Health sciences::4207 - Sports science and exercise::420702 - Exercise physiology