Starfinger, C.Chase, GeoffHann, C.E.Shaw, GeoffLambert, P.Smith, B.W.Sloth, E.Larsson, A.Andreassen, S.Rees, S.2009-03-302009-03-302008Starfinger, C., Chase, J.G., Hann, C.E., Shaw, G.M., Labert, P., Smith, B.W., Sloth, E., Larsson, A., Andreassen, S., Rees, S. (2008) Model-based identification of PEEP titrations during different volemic levels. Computer Methods and Programs in Biomedicine, 91(2), pp. 135-144.0169-2607http://hdl.handle.net/10092/2269A cardiovascular system (CVS) model has previously been validated in simulated cardiac and circulatory disease states. It has also been shown to accurately capture all main hemodynamic trends in a porcine model of pulmonary embolism. In this research, a slightly extended CVS model and parameter identification process are presented and validated in a porcine experiment of positive end-expiratory pressure (PEEP) titrations at different volemic levels. The model is extended to more physiologically represent the separation of venous and arterial circulation. Errors for the identified model are within 5% when re-simulated and compared to clinical data. All identified parameter trends match clinically expected changes. This work represents another clinical validation of the underlying fundamental CVS model, and the methods and approach of using them for cardiovascular diagnosis in critical care.encardiovascular systemcardiac modelparameter identificationintegral methodPEEPhypovolemiaJournal ArticleFields of Research::320000 Medical and Health Sciences::321000 Clinical Sciences::321003 Cardiology (incl. cardiovascular disease)Fields of Research::320000 Medical and Health Sciences::320600 Medical Physiology::320603 Systems physiologyhttps://doi.org/10.1016/j.cmpb.2008.03.005