Chase, GeoffShaw, GeoffLin, J.Doran, C.V.Hann, C.E.Robertson, M.B.Browne, P.M.Lotz, T.Wake, G.C.Broughton, R.2007-07-242007-07-242005Chase, J.G., Shaw, G.M., Lin, J., Doran, C.V., Hann, C.E., Robertson, M.B., Browne, P.M., Lotz, T., Wake, G.C., Broughton, R. (2005) Adaptive bolus-based targeted glucose regulation of hyperglycaemia in critical care. Medical Engineering and Physics, 27(1), pp. 1-11.1350-4533http://hdl.handle.net/10092/271Critically ill patients are often hyperglycemic and extremely diverse in their dynamics. Consequently, fixed protocols and sliding scales can result in error and poor control. A two-compartment glucose-insulin system model that accounts for time-varying insulin sensitivity and endogenous glucose removal, along with two different saturation kinetics is developed and verified in proof-of-concept clinical trials for adaptive control of hyperglycemia. The adaptive control algorithm monitors the physiological status of a critically ill patient, allowing real-time tight glycemic regulation. The bolus-based insulin administration approach is shown to result in safe, targeted stepwise glycemic reduction for three critically ill patients.enadaptive controlcritical careglucose-insulin system modelhyperglycemiainsulin bolusJournal ArticleFields of Research::290000 Engineering and Technology::291500 Biomedical Engineering