Anterior thalamic nuclei: a critical substrate for non-spatial paired-associate memory in rats

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dc.contributor.authorHamilton, Jenny J
dc.contributor.authorDalrymple-Alford, John
dc.date.accessioned2024-07-18T01:17:09Z
dc.date.available2024-07-18T01:17:09Z
dc.date.issued2022
dc.description.abstractInjury or dysfunction in the anterior thalamic nuclei (ATN) may be the key contributory factor in many instances of diencephalic amnesia. Experimental ATN lesions impair spatial memory and temporal discriminations, but there is only limited support for a more general role in non-spatial memory. To extend evidence on the effects of ATN lesions, we examined the acquisition of biconditional associations between odour and object pairings presented in a runway, either with or without a temporal gap between these items. Intact adult male rats acquired both the no-trace and 10-s trace versions of this non-spatial task. Intact rats trained in the trace version showed elevated Zif268 activation in the dorsal CA1 of the hippocampus, suggesting that the temporal component recruited additional neural processing. ATN lesions completely blocked acquisition on both versions of this association-memory task. This deficit was not due to poor inhibition to non-rewarded cues or impaired sensory processing, because rats with ATN lesions were unimpaired in the acquisition of simple odour discriminations and simple object discriminations using similar task demands in the same apparatus. This evidence challenges the view that impairments in arbitrary paired-associate learning after ATN lesions require the use of multimodal spatial stimuli. It suggests that diencephalic amnesia associated with the ATN stems from degraded attention to stimulus–stimulus associations and their representation across a distributed memory system.
dc.identifier.citationHamilton JJ, Dalrymple-Alford JC (2022). Anterior thalamic nuclei: A critical substrate for non-spatial paired-associate memory in rats. European Journal of Neuroscience. 56(7). 5014-5032.
dc.identifier.doihttp://doi.org/10.1111/ejn.15802
dc.identifier.issn0953-816X
dc.identifier.issn1460-9568
dc.identifier.urihttps://hdl.handle.net/10092/106213
dc.languageeng
dc.publisherWiley
dc.rightsAll rights reserved unless otherwise stated
dc.rights.urihttp://hdl.handle.net/10092/17651
dc.subjectHippocampus
dc.subjectThalamic Nuclei
dc.subjectAnterior Thalamic Nuclei
dc.subjectAnimals
dc.subjectRats
dc.subjectAmnesia
dc.subjectCues
dc.subjectMaze Learning
dc.subjectMale
dc.subjectSpatial Memory
dc.subjectbiconditional discrimination
dc.subjectextended memory system
dc.subjectimmediate early genes
dc.subjectthalamic amnesia
dc.subject.anzsrc1109 Neurosciences
dc.subject.anzsrc1701 Psychology
dc.subject.anzsrc1702 Cognitive Sciences
dc.subject.anzsrc52 - Psychology::5204 - Cognitive and computational psychology
dc.titleAnterior thalamic nuclei: a critical substrate for non-spatial paired-associate memory in rats
dc.typeJournal Article
uc.collegeFaculty of Science
uc.departmentSchool of Psychology, Speech and Hearing
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