Annotating RNA motifs in sequences and alignments

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dc.contributor.authorGardner, P.P.
dc.contributor.authorEldai, H.
dc.date.accessioned2015-04-13T21:57:18Z
dc.date.available2015-04-13T21:57:18Z
dc.date.issued2015en
dc.description.abstractRNA performs a diverse array of important functions across all cellular life. These functions include important roles in translation, building translational machinery and maturing messenger RNA. More recent discoveries include the miRNAs and bacterial sRNAs that regulate gene expression, the thermosensors, riboswitches and other cis-regulatory elements that help prokaryotes sense their environment and eukaryotic piRNAs that suppress transposition. However, there can be a long period between the initial discovery of a RNA and determining its function. We present a bioinformatic approach to characterise RNA motifs, which are critical components of many RNA structure-function relationships. These motifs can, in some instances, provide researchers with functional hypotheses for uncharacterised RNAs. Moreover, we introduce a new pro le-based database of RNA motifs - RMfam - and illustrate some applications for investigating the evolution and functional characterisation of RNA.en
dc.identifier.citationGardner, P.P., Eldai, H. (2015) Annotating RNA motifs in sequences and alignments. Nucleic Acids Research, 43(2), pp. 691-698.en
dc.identifier.doihttps://doi.org/10.1093/nar/gku1327
dc.identifier.urihttp://hdl.handle.net/10092/10304
dc.language.isoen
dc.publisherUniversity of Canterbury. Biological Sciencesen
dc.publisherUniversity of Canterbury. Biomolecular Interaction Centreen
dc.rights.urihttps://hdl.handle.net/10092/17651en
dc.subject.anzsrcFields of Research::31 - Biological sciences::3105 - Genetics::310510 - Molecular evolutionen
dc.titleAnnotating RNA motifs in sequences and alignmentsen
dc.typeJournal Article
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