This study examines the performance of nonlinear total-stress wave-propagation site response analysis for modelling site effects in physics-based ground motion simulations of the 2010-2011 Canterbury, New Zealand earthquake sequence. This approach allows for explicit modeling of 3-dimensional ground motion phenomena at the regional scale, as well as detailed site effects and soil nonlinearity at the local scale. The approach is compared to a more commonly used empirical VS30 (30 m time-averaged shear wave velocity)-based method for computing site amplification as proposed by Graves and Pitarka (2010, 2015).