Imaging Breast Microcalcifications Using Dark-Field Signal in Propagation-Based Phase-Contrast Tomography

Type of content
Journal Article
Thesis discipline
Degree name
Institute of Electrical and Electronics Engineers (IEEE)
Journal Title
Journal ISSN
Volume Title
Aminzadeh A
Arhatari BD
Maksimenko A
Hall CJ
Hausermann D
Peele AG
Fox J
Kumar B
Prodanovic Z
Dimmock M

Breast microcalcifications are an important primary radiological indicator of breast cancer. However, microcalcification classification and diagnosis may be still challenging for radiologists due to limitations of the standard 2D mammography technique, including spatial and contrast resolution. In this study, we propose an approach to improve the detection of microcalcifications in propagation-based phase-contrast X-ray computed tomography of breast tissues. Five fresh mastectomies containing microcalcifications were scanned at different X-ray energies and radiation doses using synchrotron radiation. Both bright-field (i.e. conventional phase-retrieved images) and dark-field images were extracted from the same data sets using different image processing methods. A quantitative analysis was performed in terms of visibility and contrast-to-noise ratio of microcalcifications. The results show that while the signal-to-noise and the contrast-to-noise ratios are lower, the visibility of the microcalcifications is more than two times higher in the dark-field images compared to the bright-field images. Dark-field images have also provided more accurate information about the size and shape of the microcalcifications.

Aminzadeh A, Arhatari BD, Maksimenko A, Hall CJ, Hausermann D, Peele AG, Fox J, Kumar B, Prodanovic Z, Dimmock M, Lockie D, Pavlov KM, Nesterets YI, Thompson D, Mayo SC, Paganin DM, Taba ST, Lewis S, Brennan PC, Quiney HM, Gureyev TE (2022). Imaging Breast Microcalcifications Using Dark-Field Signal in Propagation-Based Phase-Contrast Tomography. IEEE Transactions on Medical Imaging. PP. 1-1.
Ngā upoko tukutuku/Māori subject headings
ANZSRC fields of research
Fields of Research::34 - Chemical sciences::3406 - Physical chemistry::340605 - Molecular imaging (incl. electron microscopy and neutron diffraction)
Fields of Research::32 - Biomedical and clinical sciences::3202 - Clinical sciences::320222 - Radiology and organ imaging
All rights reserved unless otherwise stated