Advantages of breast cancer visualization and characterization using synchrotron radiation phase-contrast tomography

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Journal Article
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Pacilè S
Baran P
Dullin C
Dimmock M
Lockie D
Missbach-Guntner J
Quiney H
McCormack M
Mayo S
Thompson D

© International Union of Crystallography, 2018 The aim of this study was to highlight the advantages that propagation-based phase-contrast computed tomography (PB-CT) with synchrotron radiation can provide in breast cancer diagnostics. For the first time, a fresh and intact mastectomy sample from a 60 year old patient was scanned on the IMBL beamline at the Australian Synchrotron in PB-CT mode and reconstructed. The clinical picture was described and characterized by an experienced breast radiologist, who underlined the advantages of providing diagnosis on a PB-CT volume rather than conventional two-dimensional modalities. Subsequently, the image quality was assessed by 11 breast radiologists and medical imaging experts using a radiological scoring system. The results indicate that, with the radiation dose delivered to the sample being equal, the accuracy of a diagnosis made on PB-CT images is significantly higher than one using conventional techniques.

phase-contrast breast CT, synchrotron radiation, breast cancer imaging
Ngā upoko tukutuku/Māori subject headings
ANZSRC fields of research
Field of Research::11 - Medical and Health Sciences::1112 - Oncology and Carcinogenesis::111202 - Cancer Diagnosis
Field of Research::11 - Medical and Health Sciences::1103 - Clinical Sciences::110320 - Radiology and Organ Imaging
Fields of Research::40 - Engineering::4003 - Biomedical engineering::400305 - Biomedical instrumentation
Field of Research::02 - Physical Sciences::0299 - Other Physical Sciences::029904 - Synchrotrons; Accelerators; Instruments and Techniques
Fields of Research::51 - Physical sciences::5105 - Medical and biological physics::510502 - Medical physics