© 2021 John Wiley & Sons Ltd. We present the results of a study examining adolescent help-seeking intentions (HSIs), stress, subjective school achievement and life satisfaction. Using a cross-sectional design with a sample of New Zealand adolescents (n = 1601), we tested whether HSIs could mediate or moderate relations between stress and subjective achievement, and between stress and life satisfaction. We inspected these dynamics alongside different help sources (informal and formal) and domains where stress might be experienced (school and personal). Using mediation testing, findings suggest that informal HSIs have at least some influence on the relations between stress and well-being indicators, whereas formal HSIs did not. Conditional indirect effects for the mediation models (moderated mediation) revealed that gender and age did not moderate the relations between stress and informal HSIs, or between stress and well-being indicators with one exception: gender moderated the relation between personal stress and informal HSIs. In most models, tests of moderation lent support for a protective-reactive model in which HSIs reduce the adverse effects of stress on well-being indicators. Discussion focuses on modelling and promoting help-seeking activities across diverse support sources, and doing so earlier in life so that adolescents can benefit from well-honed coping strategies.