Brain magnetic resonance elastography based on Rayleigh damping material model

Abstract

This research study focuses on application of the subzone based Magnetic Resonance Elastography (MRE) using Rayleigh damped (RD) material model to quantify shear stiffness, damping behavior and elastic energy attenuation mechanism of the intracranial tissue in the in vivo healthy brain. The octahedral shear strain (OSS) SNR calculation confirmed significant attenuation of the shear strain waves in the deeper brain region. The measurement of brain viscoelastic properties revealed that ventricles exhibits much lower elasticity (0.8 kPa) than the surrounding white and gray matter (2.6 kPa). We conclude that RD MRE show promise for potential in vivo determination of different brain tissue types, and the possibility of providing additional diagnostic tools.