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    Comparison of model based and clinical blood glucose evolution during and after anhepatic status (2013)

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    12648177_homlok_et_al_BMT2013_.pdf (510.9Kb)
    Type of Content
    Conference Contributions - Other
    UC Permalink
    http://hdl.handle.net/10092/9436
    
    Publisher
    University of Canterbury. Mechanical Engineering
    Collections
    • Engineering: Conference Contributions [2338]
    Authors
    Homlok, J.
    Chase, Geoff cc
    Turi, Cs
    Benyo, B.
    show all
    Abstract

    Blood glucose (BG) control is a major difficulty during liver transplantation (LT). A model-based approach to analysis and control can enhance the efficiency of BG management during LT surgery. An existing clinically validated metabolic model was fitted to data from 8 LT patients. The reperfusion part of the post-anhepatic phase of LT shows a clear consistent dynamic rise in blood glucose (BG) level that would enable better prediction of future BG in this phase. Model fitting errors showed that the fundamental model captured all primary dynamics but parameter adjustment to reflect known conditions during LT surgery in specific phases would improve model quality.

    Citation
    Homlok, J., Chase, J.G., Turi, Cs., Benyo, B. (2013) Comparison of model based and clinical blood glucose evolution during and after anhepatic status. Graz, Austria: Biomedizinische Technik Conference (BMT 2013), 19-21 Sep 2013. 2pp.
    This citation is automatically generated and may be unreliable. Use as a guide only.
    Keywords
    liver transplant; blood glucose; reperfusion; metabolic model
    ANZSRC Fields of Research
    32 - Biomedical and clinical sciences::3201 - Cardiovascular medicine and haematology::320102 - Haematology
    32 - Biomedical and clinical sciences::3202 - Clinical sciences::320226 - Surgery
    32 - Biomedical and clinical sciences::3205 - Medical biochemistry and metabolomics::320507 - Metabolic medicine
    Rights
    https://hdl.handle.net/10092/17651

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