University of Canterbury Home
    • Admin
    UC Research Repository
    UC Library
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    1. UC Home
    2. Library
    3. UC Research Repository
    4. Faculty of Engineering | Te Kaupeka Pūhanga
    5. Engineering: Journal Articles
    6. View Item
    1. UC Home
    2.  > 
    3. Library
    4.  > 
    5. UC Research Repository
    6.  > 
    7. Faculty of Engineering | Te Kaupeka Pūhanga
    8.  > 
    9. Engineering: Journal Articles
    10.  > 
    11. View Item

    Improvements in glucose metabolism and insulin sensitivity with a low-carbohydrate diet in obese patients with type 2 diabetes (2013)

    Thumbnail
    View/Open
    12644776_Atkins Paper - REVISED.doc (150Kb)
    Type of Content
    Journal Article
    UC Permalink
    http://hdl.handle.net/10092/9024
    
    Publisher's DOI/URI
    https://doi.org/10.1080/07315724.2013.767630
    
    Publisher
    University of Canterbury. Mechanical Engineering
    Collections
    • Engineering: Journal Articles [1630]
    Authors
    Krebs, J.D.
    Bell, D.
    Hall, R.
    Parry-Strong, A.
    Docherty, P.D.
    Clarke, K.
    Chase, Geoff cc
    show all
    Abstract

    Objective: The optimal diet for weight loss in type 2 diabetes remains controversial. This study examined a low-carbohydrate, high-fat diet with detailed physiological assessments of insulin sensitivity, glycemic control, and risk factors for cardiovascular disease.

    Methods: Fourteen obese patients (body mass index [BMI] 40.6 ± 4.9 kg/m2) with type 2 diabetes were recruited for an “Atkins”-type low-carbohydrate diet. Measurements were made at 0, 12, and 24 weeks of weight, insulin sensitivity, HbA1c, lipids, and blood pressure.

    Results: Twelve completers lost a mean of 9.7 ± 1.8 kg over 24 weeks attributable to a major reduction in carbohydrates and resultant reduction in total energy intake. Glycemic control significantly improved (HbA1c -1.1 ± 0.25%) with reductions in hypoglycemic medication. Fasting glucose, homeostasis model assessment (HOMA), and area under the curve (AUC) glucose (intravenous glucose tolerance test [IVGTT]) were significantly reduced by week 12 ( p < 0.05). There were nonsignificant improvements in insulin sensitivity (SI) at week 12 ( p = 0.19) and week 24 ( p = 0.31). Systolic blood pressure was reduced (mean -10.0 mmHg between weeks 0 and 24, p = 0.13). Mean high-density lipoprotein (HDL), low-density lipoprotein (LDL), and total cholesterol all increased. The ratio of total: HDL cholesterol and triglycerides was reduced.

    Conclusion: A low-carbohydrate diet was well tolerated and achieved weight loss over 24 weeks in subjects with diabetes. Glycemic control improved with a reduction in requirements for hypoglycemic agents.

    Citation
    Krebs, J.D., Bell, D., Hall, R., Parry-Strong, A., Docherty, P.D., Clarke, K., Chase, J.G. (2013) Improvements in glucose metabolism and insulin sensitivity with a low-carbohydrate diet in obese patients with type 2 diabetes. Journal of the American College of Nutrition, 32(1), pp. 11-17.
    This citation is automatically generated and may be unreliable. Use as a guide only.
    Keywords
    Low-Carbohydrate diet; Type 2 diabetes; Weight loss; Glycaemic control; Insulin sensitivity
    ANZSRC Fields of Research
    09 - Engineering::0903 - Biomedical Engineering
    32 - Biomedical and clinical sciences::3205 - Medical biochemistry and metabolomics::320502 - Medical biochemistry - carbohydrates
    Rights
    https://hdl.handle.net/10092/17651

    Related items

    Showing items related by title, author, creator and subject.

    • Evaluation of a Glomerular Filtration Term in the DISST Model to Capture the Glucose Pharmacodynamics of an Insulin-Resistant Cohort 

      Docherty, P.D.; Chase, Geoff; Lotz, T.; Krebs, J.D. (University of Canterbury. Mechanical Engineering, 2011)
      Glomerular filtration (kidney clearance) of glucose occurs at high glucose concentrations. Thus, the applicability of glomerular filtration terms in models of insulin and glucose pharmacodynamics (PD) should be ...
    • Improving minimal model identifiability in insulin resistant patients utilising insight from the graphical structural model identifiability method 

      Docherty, P.D.; Chase, Geoff (University of Canterbury. Mechanical Engineering, 2012)
      The Minimal Model is often used to characterize participant responses to glucose by fitting model simulations to measured data. Although the model has met significant success defining test responses of normo-glucose tolerant ...
    • Effect of diagnosis on variability of ICU patients in insulin sensitivity 

      Ferenci, T.; Kovacs, L.; Benyo, B.; Le Compte, A.J.; Shaw, Geoff; Chase, Geoff (University of Canterbury. Mechanical Engineering, 2012)
      Tight glycemic control (TGC) in intensive care unit (ICU) patients represents an active research field as it has been proved its mortality and cost reduction effects. Previous works demonstrated that insulin sensitivity ...
    Advanced Search

    Browse

    All of the RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThesis DisciplineThis CollectionBy Issue DateAuthorsTitlesSubjectsThesis Discipline

    Statistics

    View Usage Statistics
    • SUBMISSIONS
    • Research Outputs
    • UC Theses
    • CONTACTS
    • Send Feedback
    • +64 3 369 3853
    • ucresearchrepository@canterbury.ac.nz
    • ABOUT
    • UC Research Repository Guide
    • Copyright and Disclaimer
    • SUBMISSIONS
    • Research Outputs
    • UC Theses
    • CONTACTS
    • Send Feedback
    • +64 3 369 3853
    • ucresearchrepository@canterbury.ac.nz
    • ABOUT
    • UC Research Repository Guide
    • Copyright and Disclaimer