Hydrolysis of peptide bonds : participation of a carboxyl group in amide hydrolysis

Type of content
Theses / Dissertations
Publisher's DOI/URI
Thesis discipline
Chemistry
Degree name
Doctor of Philosophy
Publisher
University of Canterbury. Chemistry
Journal Title
Journal ISSN
Volume Title
Language
Date
1967
Authors
Jones, F. W.
Abstract

In order to assess the effect of substituents on the participation of a neighbouring carboxyl group in the hydrolysis of amides, seventeen substituted succinamic acids have been prepared. Their rates of hydrolysis have been determined at three temperatures, and their rates and thermodynamic functions have been correlated at 70°. The mechanism of the hydrolysis has been discussed and the effect of the substituents interpreted in terms of their bulk and electronic characters.

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Ngā upoko tukutuku/Māori subject headings
ANZSRC fields of research
Rights
Copyright F. W. Jones