3:5 - dimethyl xylose (1949)
AuthorsReeves, J. E.show all
Condensation of sugar alcohols with aldehydes was first observed by Meunier, 1888, who successfully formed a cyclic acetal from mannitol and benzaldehyde [diagram]. This condensation with aldehydes or ketones has since been found to be perfectly general for sugars and other polyhydroxy compounds in the presence of an acidic dehydrating agent. By the blocking of two or four positions in the sugar molecule with these easily removed ketone groups, a method of synthesis of substituted sugar derivatives thus suggested itself.