Optically active alpha-beta-gamma-trimethyl-glutaconic acid (1948)
AuthorsNottingham, P. C. M.show all
The Mobility of the hydrogen atom in the three carbon system. So far as has been investigated, reaches its maximum in glutaconic acid where the three-carbon system is activated by two terminal keto-enol systems so that the whole is a heptad system. Due to the mobility of the hydrogen atom, the chemistry of the glutaconic acids displays many interesting features. With glutaconic acid it’s self the mobility is such that only one form of the acid, the trans, is stable, although the cis form has been obtained by careful hydration of the anhydride (alanchowaski Ber 1929, 62B, 1323). Introduction of electron releasing substituents reduced this mobility so that in some cases most of the theoretically possible forms have been isolated.