Virtual Patients and Clinical Trial Simulations to Improve Safety of Glucose Control in Intensive Care (2012)

Type of Content
Journal ArticlePublisher
University of Canterbury. Mechanical EngineeringISSN
2040-2295Collections
Abstract
Despite the potential clinical benefits of normalizing blood glucose in critically ill patients, the risk of hypoglycemia is a major barrier to widespread clinical adoption of accurate glycemic control. To compare five glucose control protocols, a validated insulin-glucose system model was employed to perform simulated clinical trials. STAR, SPRINT, UNC, Yale and Glucontrol protocols were assessed over a medical-surgical intensive care unit patient cohort. Results were interpreted separately for patients with low to high sensitivity to insulin, and low to high variability in metabolic state. STAR and SPRINT provided good glucose control with risk of severe hypoglycemia less than 0.05% across all patient groups. UNC also achieved good control for patients with low and medium levels of insulin sensitivity (SI), but risk of severe hypoglycemia was raised for patients with high SI. Glucontrol showed degradation of performance for patients with high metabolic variability.
Citation
Fisk, L., Le Compte, A.J., Shaw, G.M., Chase, J.G. (2012) Virtual Patients and Clinical Trial Simulations to Improve Safety of Glucose Control in Intensive Care. Journal of Healthcare Engineering, 3(3), pp. 415-430.This citation is automatically generated and may be unreliable. Use as a guide only.
Keywords
critical care; glycemic control; virtual trialsANZSRC Fields of Research
40 - Engineering::4003 - Biomedical engineering::400303 - Biomechanical engineering32 - Biomedical and clinical sciences::3202 - Clinical sciences::320212 - Intensive care
32 - Biomedical and clinical sciences::3205 - Medical biochemistry and metabolomics::320502 - Medical biochemistry - carbohydrates
32 - Biomedical and clinical sciences::3202 - Clinical sciences::320208 - Endocrinology
32 - Biomedical and clinical sciences::3201 - Cardiovascular medicine and haematology::320102 - Haematology
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