Synthetic approaches towards the benzodioxepin core of the strobilurin family
Degree GrantorUniversity of Canterbury
Degree NameMaster of Science
With the earth's population growing at a great rate, ways to increase the yields of plant matter from commercial horticulture are needed. A variety of methods have been investigated towards this end. Many of these methods have considerable associated risks. The genetic engineering of higher-yielding crops or the extensive use of fertilisers are two examples of this. One method which is often overlooked is the use of pesticides or fungicides to minimise the deleterious effects that plant pathogens have on crops. The fungal kingdom contains many members which are pathogenic to plants and as such, treatment of fungal infestations using commercial fungicides was a US$6 billion industry in 1996. One of the principal difficulties with the use of commercial fungicides is the development of wide-spread fungal resistance to their cytotoxic effects. The best method for countering this resistance is to develop new classes of fungicides with novel modes of action. Their judicious use would then offer a solution to the increasingly wide-spread problem of fungicidal resistance. However, the development of an entirely novel class of fungicide is a rare event. Most new fungicides involve structural variation of previously used cytotoxins and therefore have limited use in the alleviation of fungal resistance.