A study of antibiotic compounds in New Zealand plants
Degree GrantorUniversity of Canterbury
Degree NameDoctor of Philosophy
The antifungal polyacetylene, falcarindiol, ( (9Z) – heptadeca -1,9-diene-4,6-diyn-3,8-diol) was isolated from the New Zealand native plant Schefflera digitata (Araliaceae). The structure was established by CIMS, 13 C-NMR and ¹H-NMR. Falcarindiol was found to be present in the leaves at a concentration of 0.15 to 0.17% of the fresh weight. This compound exhibited selective antifungal activity against dermatophytes with minimum inhibitory concentrations of 5 μg/ml against Microsporum canis, M. gypseum, M. nanum, Trichophyton mentagrophytes, T. rubrum, T. erinacei, T. tonsurans and Epidermophyton floccosum, and causes gross disorganization of sensitive fungal spores. The spectrum of antibiotic activity of falcarindiol against other micro-organisms and also the screening of New Zealand Pseudopanax species for antifungal activity are reported.