Cardiovascular system modelling of heart-lung interaction during mechanical ventilation (2006)
AuthorsSmith, B.W., Andreassen, S., Shaw, G.M., Rees, S.E., Chase, J.G.show all
Choosing suitable ventilation strategies for critically ill patients with lung disorders involves considering the difficult and poorly understood trade-off between achieving adequate ventilation, while maintaining suitable perfusion. This study presents a minimal cardiovascular system model that includes variations in pulmonary vascular resistance during mechanical ventilation. The model is shown to capture transient haemodynamics from experimentally measured data. It also enables investigation into the effects of time varying resistance on pulmonary haemodynamics. The study shows the potential usefulness of this model in a tool to assist clinical staff in optimising ventilation pressures while maintaining adequate pulmonary perfusion
CitationSmith, B.W., Andreassen, S., Shaw, G.M., Rees, S.E., Chase, J.G. (2006) Cardiovascular system modelling of heart-lung interaction during mechanical ventilation. Reims, France: 6th IFAC Symposium on Modelling and Control in Biomedical Systems (Including Biological Sciences) (MCBMS'06), 19-22 Sep 2006. 6 pp.
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KeywordsBiomedical systems; Physiological models; Dynamic modelling; Dynamic models; Lumped constant models
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