Identification of time-varying cardiac disease state using a minimal cardiac model with reflex actions

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Conference Contributions - Published
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Publisher
University of Canterbury. Mechanical Engineering.
Journal Title
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Date
2006
Authors
Hann, C.E.
Andreassen, S.
Smith, B.W.
Shaw, Geoff
Chase, Geoff
Jensen, P.L.
Abstract

A minimal cardiac model that accurately captures the essential cardio- vascular system dynamics has been developed. Standard parameter identification methods for this model are highly non-linear and non-convex, hindering clinical application, given the limited measurements available in an intensive care unit. This paper presents an integral based identification method that transforms the problem into a linear, convex problem. Five common disease states including four fundamental types of shock, are identified to within 10% without false identification. Clinically, it enables medical staff to rapidly obtain a patient specific model to assist in diagnosis and therapy selection.

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Citation
Hann, C.E., Andreassen, S., Smith, B.W., Shaw, G.M., Chase, J.G., Jensen, P.L. (2006) Identification of Time-Varying Cardiac Disease State Using a Minimal Cardiac Model with Reflex Actions. Newcastle, Australia: 14th IFAC Symposium on System Identification (SYSID 2006), 29-31 Mar 2006. 4pp.
Keywords
Biomedical systems, Physiological models, Integrals, Parameter identification, Diagnosis
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