Validation of a Model-based Virtual Trials Method for Tight Glycemic Control in Intensive Care (2010)
PublisherUniversity of Canterbury. Mechanical Engineering
In-silico virtual trials offer significant advantages in cost, time and safety. However, no such method has been truly validated with clinical data. This study tests 2 matched cohorts from an independent ICU treated with 2 different glycaemic control protocols. The goal is to validate the in-silico virtual trials model and methods, including the underlying assumptions. A retrospective analysis used records from a 211 patient subset of the Glucontrol trial in Liege, Belgium. Glucontrol-A (N = 142) targeted a BG range of 4.4-6.1 mmol/L and Glucontrol-B (N = 69) targeted 7.8-10.0 mmol/L. Cohorts were matched by APACHE II score, but the Glucontrol A cohort was slightly older (p = 0.0352). Results showed high correlation between self- and cross-validation virtual trials and clinical results. The virtual trials models and methods are thus validated on independent data.
CitationSuhaimi, F.M., Chase, J.G., LeCompte, A.J., Preiser, J-C, Lin, J., Shaw, G.M. (2010) Validation of a Model-based Virtual Trials Method for Tight Glycemic Control in Intensive Care. Coventry, UK: UKACC International Conference on CONTROL 2010, 7-10 Sep 2010.
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KeywordsIntensive Care; in-silico trials; virtual trials; hyperglycaemia; model; validation
ANZSRC Fields of Research32 - Biomedical and clinical sciences::3202 - Clinical sciences::320212 - Intensive care
32 - Biomedical and clinical sciences::3201 - Cardiovascular medicine and haematology::320102 - Haematology
09 - Engineering::0913 - Mechanical Engineering
40 - Engineering::4003 - Biomedical engineering::400303 - Biomechanical engineering
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