Equal but Opposite: Acute Anxiolytic versus Chronic Anxiogenic Effects Following Adolescent Fluoxetine Use (2010)
Type of ContentTheses / Dissertations
Degree NameMaster of Science
PublisherUniversity of Canterbury. Psychology
Fluoxetine (FIx) is cunently one the most commonly prescribed antidepressant medications for adolescents suffering from various emotional disorders. FIx has been approved by the United States Food and Drug Administration (FDA) for the treatment of adolescent major depressive disorder (MDD) and obsessive compulsive disorder (OeD), despite limited research into the possible long-term effects of this psychoactive substance on the developing adolescent brain. The cunent study aimed to investigate the effects of adolescent FIx exposure on later anxietylike behaviour in rats. The current study involved the oral administration of FIx hydrochloride, via drinking water, to Inale and female adolescent PVG/C Hooded rats. There were three treatment conditions with differing FIx treatment periods (early, late or early plus late), and a control group. Immediately following FIx treatment, all groups were tested on an acute open-field test. The rats were then tested on two later occasions during adulthood on a battery of anxiety-related tests: the light-dark box test, the responsiveness to brightness change Y -maze and the social interaction test (SIT). On the acute open-field test, the FIx-treated rats displayed greater ambulation and possibly lower corner square occupancy, suggestive of an acute anxiolytic effect of FIx. The chronic effects testing suggested that rats treated during the late phase of adolescence, either alone or in combination with early treatlnent, were the Inost affected by FIx. The late FIx-treated group spent less time in the light during the light-dark box test, and defecated more than other groups during the SIT. In addition, the males within the late FIx-treated group spent significantly more time within the comer squares and less time within the centre squares of the SIT apparatus than males from the early FIx-treated group. Overall this study suggests that the long-term effects of adolescent FIx use are anxiogenic.
RightsCopyright Amber Jane Rowse
Showing items related by title, author, creator and subject.
The Acute, Chronic, and Teratological Effects of Methamphetamine on Aggressive Behaviour in Adolescent Hooded Rats Lowther, Courtney (University of Canterbury. Psychology, 2012)Methamphetamine is a widely abused psychostimulant often associated with aggressive, violent, and criminal behaviour. Research into the effects of adolescent methamphetamine use on aggressive behaviour is limited. This ...
Anxiolytic effects of chronic treatment with Hypericum perforatum (St John’s Wort) tincture in male and female rats. Shen, Jie Hua (University of Canterbury, 2020)Given high prevalence of anxiety disorders, it is important to identify effective alternative treatments due to the current limitations of pharmacological and psychological interventions. Worldwide, Hypericum perforatum ...
The effect of acute and chronic elevation of temperature on aspects of the physiology of Antarctic nototheniid fishes Lowe, Cara J. (University of Canterbury. Zoology, 2004)The notothenioid fishes, which dominate the upper shelf habitats of the Antarctic Continental Shelf, have evolved in a relatively thermally stable environment for at least 10-15 million years. With the upper lethal limits ...