Modelling Acute Renal Failure using Blood and Breath Biomarkers in Rats (2009)
AuthorsMoorhead, K.T., Scotter, J., Chase, J.G., Hann, C.E., Hill, J., Endre, Z.show all
This paper compares three methods for estimating renal function, tested in rats. Acute Renal Failure (ARF) was induced via a 60-minute bilateral renal artery clamp in 8 Sprague-Dawley rats and renal function was monitored for 1 week post-surgery. A two-compartment model was developed for estimating renal function via a bolus injection of a radio-labelled inulin tracer, and was compared with the current gold standard plasma creatinine measurement, modified using the Cockcroft-Gault equation for rats. These two methods were compared with Selected Ion Flow Tube-Mass Spectrometry (SIFT-MS) monitoring of breath analytes. Determination of renal function via SIFT-MS is desirable since results are available non-invasively and in real time. Relative decreases in renal function show excellent correlation between methods, and indicate good promise for fast, non-invasive determination of renal function via breath testing.
CitationMoorhead, K.T., Scotter, J., Chase, J.G., Hann, C.E., Hill, J., Endre, Z. (2009) Modelling Acute Renal Failure using Blood and Breath Biomarkers in Rats. Aalborg, Denmark: 7th IFAC Symposium on Modelling and Control in Biomedical Systems (MCBMS 09), 12-14 Aug 2009.
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