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    Patient-specific modelling of the cardiovascular system – application to septic shock with a minimal data set

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    Author
    Desaive, T.
    Chase, J.G.
    Starfinger, C.
    Lambermont, B.
    Ghuysen, A.
    Kolh, P.
    Dauby, P.C.
    Shaw, G.M.
    Hann, C.E.
    Date
    2009
    Permanent Link
    http://hdl.handle.net/10092/3781

    We use a previously validated cardiovascular system (CVS) model and parameter identification method to identify the pig-specific parameters during induced endotoxic shock. Six anesthetized healthy pigs weighing 20-30 kg received a 0.5- mg/kg endotoxin infusion over a period of 30 mins from T0 to T30. Only right heart measurements were obtained and thus significantly less data was available for the model parameter identification compared to previous studies. Errors for the identified model are within 8% when the model is identified from data, re-simulated and then compared to the clinically measured data. All identified parameter trends match physiologically expected changes. This work represents a further clinical validation for this model-based approach to cardiovascular diagnosis and therapy guidance in monitoring endotoxic disease states.

    Subjects
    cardiovascular system
     
    mathematical model
     
    parameter identification
     
    septic shock
     
    Fields of Research::320000 Medical and Health Sciences::321000 Clinical Sciences::321003 Cardiology (incl. cardiovascular disease)
     
    Fields of Research::290000 Engineering and Technology::291500 Biomedical Engineering::291504 Biomechanical engineering
     
    Fields of Research::230000 Mathematical Sciences::230100 Mathematics
    Collections
    • Engineering: Conference Contributions [1920]
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    https://canterbury.libguides.com/rights/ir

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