Patient-specific modelling of the cardiovascular system – application to septic shock with a minimal data set

Abstract

We use a previously validated cardiovascular system (CVS) model and parameter identification method to identify the pig-specific parameters during induced endotoxic shock. Six anesthetized healthy pigs weighing 20-30 kg received a 0.5- mg/kg endotoxin infusion over a period of 30 mins from T0 to T30. Only right heart measurements were obtained and thus significantly less data was available for the model parameter identification compared to previous studies. Errors for the identified model are within 8% when the model is identified from data, re-simulated and then compared to the clinically measured data. All identified parameter trends match physiologically expected changes. This work represents a further clinical validation for this model-based approach to cardiovascular diagnosis and therapy guidance in monitoring endotoxic disease states.