Corticosteroids and Insulin Resistance in the ICU (2009)
Type of ContentConference Contributions - Published
PublisherUniversity of Canterbury. Mechanical Engineering
AuthorsPretty, C.G., Chase, J.G., Lin, J., Shaw, G.M., LeCompte, A.J., Razak, N. Parente, J.show all
Corticosteroids reduce insulin sensitivity in healthy individuals by 30- 62-percent. The aim of this research was to use model-based methods to determine whether this reduction is also true in critically ill patients and how it may affect tight glycaemic control. A clinically validated model-based measure of insulin sensitivity was used to quantify changes between two matched cohorts of 40 intensive care unit (ICU) patients from Christchurch hospital. A 9-percent reduction in median insulin sensitivity was seen between the control cohort and patients receiving corticosteroids (per patient dose equivalent to 160mg/d of hydrocortisone). On a per-patient basis 11- 22-percent reductions were observed with higher percentile patients having greater suppression of insulin sensitivity. This research has shown that corticosteroids cause a much lower reduction in insulin sensitivity for critically ill patients compared to healthy controls and may thus have far less impact than suspected on glycaemic control in the ICU setting.
CitationPretty, C.G., Chase, J.G., Lin, J., Shaw, G.M., LeCompte, A.J., Razak, N. Parente, J. (2009) Corticosteroids and Insulin Resistance in the ICU. Aalborg, Denmark: 7th IFAC Symposium on Modeling and Control in Biomedical Systems (MCBMS09), 12-14 Aug 2009. 7, 1, 6pp.
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