Structural reassignment of an "unusual" derivative of 3-methyl-5-phenylpyrazol-5-one (Edaravone)
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Journal Article
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Publisher
University of Canterbury. Chemistry.
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Date
2006
Authors
Burgess, J.
Steel, P.J.
Abstract
The structure of the major product from the reaction of 4-bromo-3-methyl-1-phenylpyrazol-5-one (1) with ethyl cyanoacetate is shown, by means of an X-ray crystal structure determination, to be the spirocyclic compound 4, rather than the previously proposed isomer 3.
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Citation
Burgess, J., Steel, P.J. (2006) Structural reassignment of an "unusual" derivative of 3-methyl-5-phenylpyrazol-5-one (Edaravone). Tetrahedron Letters, 47(25), pp. 4107-4108.
Keywords
pyrazolone, spiro compound, crystal structure