Recent developments of viable and low-cost seismic retrofit solutions within a performance-based approach, suggest the possibility to implement “standardized” solutions at a regional scale. However, different and complex criteria should be considered in order to define the most effective retrofit strategy able to minimize the overall risk. First of all, the feasibility of the intervention should be investigated accounting for the actual limits of the available resources, e.g. financial, physical or human, which could represent a critical constraint for a large scale intervention. Secondly, it should be taken into account that the benefits and costs associated with seismic risk mitigation strategies might have different impacts onto the local and regional economy, while affecting a wider variety of stakeholders, if not a substantial portion of the society as a whole. In this contribution, a multicriteria approach is proposed as a valuable tool to select an effective retrofit strategy while accounting for both monetary and non-monetary-based criteria. The effectiveness of alternative retrofit options is assessed on a case study area using a multi-criteria approach and compared with the results from a more standard cost-benefit approach.