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    Cerebral Haemodynamics and Auto-Regulatory Models of the Circle of Willis (2003)

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    Type of Content
    Journal Article
    UC Permalink
    http://hdl.handle.net/10092/299
    
    Publisher
    University of Canterbury. Mechanical Engineering.
    ISSN
    0028-8446
    Collections
    • Engineering: Journal Articles [1630]
    Authors
    Moorhead, K.T.
    Doran, C.V.
    Chase, Geoff cc
    David, T.
    show all
    Abstract

    The Circle of Willis (CoW) is a ring-like structure of blood vessels found beneath the hypothalamus at the base of the brain distributing blood to the cerebral hemispheres. A one-dimensional computational fluid dynamic [1-D CFD] model is developed to capture the auto-regulation dynamics that maintain blood perfusion pressure with a goal of developing diagnostic tools for stroke prediction.

    The afferent and circulus arteries have constant resistances, and the efferent arteries have variable resistors limited to changes in radius of up to 40% to capture auto-regulatory behaviour. Auto-regulation is modelled by feedback control coupled with peripheral resistance dynamics to create a non-linear system. Solutions are obtained far more quickly than higher dimensional CFD models via a unique non-linear solution method. The overall model enables simulation of different CoW geometries for different patient conditions.

    The CoW is simulated with a 20mmHg arterial pressure drop in the right internal carotid artery for the balanced configuration and each case where a single circulus vessel is omitted. Results match the 20% drop in flowrate, and 20 second response time from published clinical data and prior research. No single omission leads to failure in reaching the required efferent flowrates, highlighting the overall robustness of this arterial structure. A high stroke risk case, however, fails to achieve the required flowrate in the left posterior communicating artery (LPCA2), representing a potential stroke. All of these results agree well with known clinical results, indicating the potential of this model for pre-determining potential outcomes of surgical or other procedures.

    Citation
    Moorhead, K.T., Doran, C.V., Chase, J.G., David, T. (2003) Cerebral Haemodynamics and Auto-Regulatory Models of the Circle of Willis. New Zealand Medical Journal, 116(1174), pp. 443.
    This citation is automatically generated and may be unreliable. Use as a guide only.
    Rights
    https://hdl.handle.net/10092/17651

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    • Lumped Parameter and Feedback Control Models of the Auto-Regulatory Response in the Circle of Willis 

      Moorhead, K.T.; Doran, C.V.; Chase, Geoff; David, T. (University of Canterbury. Mechanical Engineering., 2004)
      The Circle of Willis is a ring-like structure of blood vessels found beneath the hypothalamus at the base of the brain. Its main function is to distribute oxygen-rich arterial blood to the cerebral mass. A one-dimensional ...
    • Lumped Parameter and Feedback Control Models of the Auto-Regulatory Response in the Circle of Willis 

      Moorhead, K.T.; Doran, C.V.; Chase, Geoff; David, T. (University of Canterbury. Mechanical Engineering., 2003)
      The Circle of Willis (CoW) is a ring-like structure of blood vessels found beneath the hypothalamus at the base of the brain, which distributes blood to the cerebral mass. Simple models of cerebral blood flow dynamics would ...
    • Impact of decentralised control in cerebral blood flow auto-regulation using 1D and 3D models 

      Moorhead, K.T.; Moore, S.M.; Chase, Geoff; David, T.; Fink, J. (University of Canterbury. Mechanical Engineering., 2005)
      The Circle of Willis is a ring-like structure of blood vessels at the base of the brain that distributes oxygen-rich arterial blood to the cerebral mass at a specific rate. One dimensional (1D) and three-dimensional (3D) ...
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