University of Canterbury Home
    • Admin
    UC Research Repository
    UC Library
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    1. UC Home
    2. Library
    3. UC Research Repository
    4. Faculty of Engineering | Te Kaupeka Pūhanga
    5. Engineering: Journal Articles
    6. View Item
    1. UC Home
    2.  > 
    3. Library
    4.  > 
    5. UC Research Repository
    6.  > 
    7. Faculty of Engineering | Te Kaupeka Pūhanga
    8.  > 
    9. Engineering: Journal Articles
    10.  > 
    11. View Item

    A Subcutaneous Insulin Pharmacokinetic Model for Computer Simulation in a Diabetes Decision Support Role: Validation and Simulation (2008)

    Thumbnail
    View/Open
    12611864_SC Model 2 - PROOF.pdf (1.814Mb)
    Type of Content
    Journal Article
    UC Permalink
    http://hdl.handle.net/10092/2613
    
    Publisher
    University of Canterbury. Mechanical Engineering.
    ISSN
    1932-2968
    Related resource(s)
    http://www.journalofdst.org/Journal/pdf/July2008/VOL-2-4-ORG13-WONG2.pdf
    Collections
    • Engineering: Journal Articles [1630]
    Authors
    Chase, Geoff cc
    Hann, C.E.
    Shaw, Geoff cc
    Lotz, T.F.
    Lin, J.
    Le Compte, A.J.
    Wong, J.
    show all
    Abstract

    Objective: The goal of this study was to validate a previously derived and identified physiological subcutaneous (SC) insulin absorption model for computer simulation in a clinical diabetes decision support role using published pharmacokinetic summary measures. Methods: Validation was performed using maximal plasma insulin concentration (Cmax) and time to maximal concentration (tmax) pharmacokinetic summary measures. Values were either reported or estimated from 37 pharmacokinetic studies over six modeled insulin types. A validation comparison was made to equivalent pharmacokinetic summary measures calculated from model generated curves fitted to respective plasma insulin concentration data. The validation result was a measure of goodness of fit. Validation for each reported study was classified into one of four cases. Results: Of 37 model fits, 22 were validated on both the Cmax and the tmax summary measures. Another 6 model fits were partially validated on one measure only due to lack of reporting on the second measure with errors to reported or estimated ranges of <12%. Another 7 studies could not be validated on either measure because of inadequate reported clinical data. Finally, 2 separate model fits to data from the same study failed the validation with 90 and 71% error on tmax only, which was likely caused by protocol-based error. No model fit failed the validation on both measures.

    Citation
    Wong, J., Chase, J.G., Hann, C.E., Shaw, G.M., Lotz, T.F., Lin, J., Le Compte, A.J. (2008) A Subcutaneous Insulin Pharmacokinetic Model for Computer Simulation in a Diabetes Decision Support Role: Validation and Simulation. Journal of Diabetes Science and Technology, 2(4), pp. 672-680.
    This citation is automatically generated and may be unreliable. Use as a guide only.
    Keywords
    diabetes; compartmental models; hyperglycemia; insulin; blood glucose; simulation; subcutaneous injection; decision support
    Rights
    https://hdl.handle.net/10092/17651

    Related items

    Showing items related by title, author, creator and subject.

    • Development of a Clinical Type 1 Diabetes Metabolic System Model and in Silico Simulation Tool 

      Wong, X.W.; Chase, Geoff; Hann, C.E.; Lotz, T.; Lin, J.; Le Compte, A.J.; Shaw, Geoff (University of Canterbury. Mechanical Engineering., 2008)
      Objectives: To develop a safe and effective protocol for the clinical control of Type 1 diabetes using conventional self-monitoring blood glucose (SMBG) measurements, and multiple daily injection (MDI) with insulin ...
    • Model predictive glycaemic regulation in critical illness using insulin and nutrition input: a pilot study 

      Wong, X-W.; Chase, Geoff; Shaw, Geoff; Hann, C.E.; Lotz, T.; Lin, J.; Singh-Levett, I.; Hollingsworth, L.J.; Wong, O.S.W.; Andreassen, S. (University of Canterbury. Chemical and Process Engineering.University of Canterbury. Mechanical Engineering., 2006)
      This paper develops and presents a pilot study of a long-term controller for safe regulation of glycaemia under elevated insulin resistance and glucose intolerance in critically ill patients by modulating enteral nutrition ...
    • Simulation and initial proof-of-concept validation of a glycaemic regulation algorithm in critical care 

      Wong, X.W.; Chase, Geoff; Shaw, Geoff; Hann, C.E.; Lotz, T.; Lin, J.; Singh-Levett, I.; Hollingsworth, L. (University of Canterbury. Mechanical Engineering., 2008)
      Glycaemic control can reduce mortality in intensive care by 45%. A model-based control algorithm utilising insulin and nutritional glucose inputs is presented. Simulated long-term gluco-regulatory trials with the virtual-patient ...
    Advanced Search

    Browse

    All of the RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThesis DisciplineThis CollectionBy Issue DateAuthorsTitlesSubjectsThesis Discipline

    Statistics

    View Usage Statistics
    • SUBMISSIONS
    • Research Outputs
    • UC Theses
    • CONTACTS
    • Send Feedback
    • +64 3 369 3853
    • ucresearchrepository@canterbury.ac.nz
    • ABOUT
    • UC Research Repository Guide
    • Copyright and Disclaimer
    • SUBMISSIONS
    • Research Outputs
    • UC Theses
    • CONTACTS
    • Send Feedback
    • +64 3 369 3853
    • ucresearchrepository@canterbury.ac.nz
    • ABOUT
    • UC Research Repository Guide
    • Copyright and Disclaimer