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    Micro-patterning of polymer-based optical oxygen sensors for lab-on-chip applications

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    12607383_Proceedings_MicroPattPolOxygenSensorForLOC_Nock_ProcSPIE(2007).pdf (306.1Kb)
    Author
    Nock, V.M.
    Blaikie, R.J.
    David, T.
    Date
    2007
    Permanent Link
    http://hdl.handle.net/10092/2541

    Soft-lithography and plasma etching with reactive ions were used to fabricate a polymer microfluidic cell-culture bioreactor with integrated optical oxygen sensor. Platinum (II) octaethylporphyrin ketone (PtOEPK) suspended in a microporous polystyrene (PS) matrix was spin-coated to form sensor films of variable thickness from 1.1 µm to 400 nm on glass substrates. Sensor films were found to be smooth and well adhered. Arbitrary patterns with a minimum feature size of 25 µm could be routinely replicated in the PtOEPK/PS layer using polydimethylsiloxane (PDMS) elastomer stamps as etch masks in a reactive ion etcher. No effect of plasma patterning and sensor integration by plasma bonding on the sensor signal could be observed. Detection of different gaseous and dissolved oxygen concentrations with the patterned sensor followed linear Stern-Volmer behavior. Dynamic measurement of sensor intensity as a function of different oxygen concentration showed good reproducibility and a nearly instantaneous response to gas changes. For gaseous and dissolved oxygen measurement with a patterned 400 nm thick film I0/I100 ratios of 3.2 and 2.7 were found, respectively.

    Subjects
    optical oxygen sensor
     
    PtOEPK in PS
     
    micro-patterning
     
    RIE
     
    sensor integration
     
    fluorescence microscopy
     
    Fields of Research::290000 Engineering and Technology::291800 Interdisciplinary Engineering::291804 Nanotechnology
     
    Fields of Research::290000 Engineering and Technology::299900 Other Engineering and Technology::299903 Biosensor technolgies
     
    Fields of Research::290000 Engineering and Technology::291500 Biomedical Engineering::290599 Biomedical engineering not elsewhere classified
    Collections
    • Engineering: Conference Contributions [2012]
    Rights
    https://hdl.handle.net/10092/17651

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