Blood glucose modelling and control for pre-term infants
Hyperglycemia (high blood sugar levels) occurs in 40-80% of very low birth weight infants in the neonatal intensive care unit (NICU). This condition has been linked to mortality and morbidities including retinopathy of prematurity, osmotic diuresis, reduced immune system performance and sepsis. Insulin therapy can control hyperglycaemia and promote growth, but increases the risk of dangerous low levels of blood glucose. The goal of this model is to provide dosing recommendations for attending clinicians. The model is used for two tasks: predict future blood glucose concentration for real-time control, and perform simulated trials to optimise control strategies.