Now showing items 1-6 of 6
7,8-Dihydroneopterin and its effect on the formation of foam cells.
(University of Canterbury. School of Biological Sciences, 2015)
Atherosclerosis (Heart Disease) is an inflammatory disease caused by the formation of plaque within the arterial wall. In response to inflammation, monocytes enter the artery wall, differentiate into macrophages and take ...
Macrophage Activation and Differentiation with Cholesterol Crystals
(University of Canterbury. Biological Sciences, 2012)
Cholesterol crystals have been linked to activation of the NLRP3 inflammasome and the formation of foreign body giant cells (FBGCs). It has been hypothesized that FBGCs have a role in advanced atherosclerotic plaque ...
7,8-Dihydroneopterin-mediated protection of low density lipoprotein, but not human macrophages, from oxidative stress
(University of Canterbury. Biological Sciences, 2006)
Any lipoproteins and cells present in the inflammatory environment of atherosclerotic plaques are likely to be exposed to high levels of oxidative stress. As 7,8-dihydroneopterin (7,8-NP) is synthesized by interferon-Î³ ...
A model of complex plaque formation: 7,8-Dihydroneopterin protects human monocyte-derived macrophages from oxidised low density lipoprotein-induced death
(University of Canterbury. School of Biological Sciences, 2008)
Plasma neopterin is an excellent marker of inflammation and is found in elevated levels in plasma of patients with cardiovascular disease. Neopterin originates as the oxidation product of 7,8-dihydroneopterin (7,8-NP), ...
Inhibition of macrophage metabolism by oxLDL
(University of Canterbury. School of Biological Sciences, 2012)
Intracellular oxidative stress is induced by oxidised low density lipoprotein (oxLDL) in macrophages. In the atherosclerotic lesions, this oxLDL dependent oxidative stress appears to cause macrophage cell death, a key ...
Formation, Transport and Detection of 7,8-Dihydroneopterin
(University of Canterbury. School of Biological Sciences, 2013)
Atherosclerosis is a chronic inflammatory disease leading to plaque buildup in the major arteries. The plaques consist of cholesterol, calcium, inflammatory cells, extracellular matrix and fibrous material. Under ...