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Macrophage Activation and Differentiation with Cholesterol Crystals
(University of Canterbury. Biological Sciences, 2012)
Cholesterol crystals have been linked to activation of the NLRP3 inflammasome and the formation of foreign body giant cells (FBGCs). It has been hypothesized that FBGCs have a role in advanced atherosclerotic plaque ...
Inhibition of macrophage metabolism by oxLDL
(University of Canterbury. School of Biological Sciences, 2012)
Intracellular oxidative stress is induced by oxidised low density lipoprotein (oxLDL) in macrophages. In the atherosclerotic lesions, this oxLDL dependent oxidative stress appears to cause macrophage cell death, a key ...