Now showing items 1-2 of 2
Design, Synthesis and Characterisation of Inhibitors of 3-Deoxy-D-arabino-Heptulosonate 7-Phosphate Synthase
(University of Canterbury. Chemistry, 2007)
The enzyme 3-deoxy D-arabino-heptulosonate 7-phosphate (DAH7P) synthase catalyses the first step of the shikimate pathway. This pathway lies at the heart of bacterial metabolism, and is responsible for the synthesis of a ...
Molecular Switches: The Design, Synthesis and Biological Applications of Photoactive Enzyme Inhibitors
(University of Canterbury. Chemistry, 2006)
This thesis examines the design, synthesis and biological applications of a series of inhibitors which incorporate an azobenzene photoswitch, a peptidyl backbone and a trifluoromethyl ketone warhead. The photoswitch can ...