Now showing items 1-3 of 3
A model of complex plaque formation: 7,8-Dihydroneopterin protects human monocyte-derived macrophages from oxidised low density lipoprotein-induced death
(University of Canterbury. School of Biological Sciences, 2008)
Plasma neopterin is an excellent marker of inflammation and is found in elevated levels in plasma of patients with cardiovascular disease. Neopterin originates as the oxidation product of 7,8-dihydroneopterin (7,8-NP), ...
Macrophage Activation and Differentiation with Cholesterol Crystals
(University of Canterbury. Biological Sciences, 2012)
Cholesterol crystals have been linked to activation of the NLRP3 inflammasome and the formation of foreign body giant cells (FBGCs). It has been hypothesized that FBGCs have a role in advanced atherosclerotic plaque ...
7,8-Dihydroneopterin and its effect on the formation of foam cells.
(University of Canterbury. School of Biological Sciences, 2015)
Atherosclerosis (Heart Disease) is an inflammatory disease caused by the formation of plaque within the arterial wall. In response to inflammation, monocytes enter the artery wall, differentiate into macrophages and take ...