Now showing items 1-4 of 4
Molecular Modelling for Enzyme Inhibition: A Search for a New Treatment for Cataract and New Antimicrobials and Herbicides
(University of Canterbury. Chemistry, 2010)
There have been several reports that cataract development results from unregulated Ca2+ mediated degradation of lens crystallins. The calpain isoform m-calpain, a cysteine protease, is known to be a major player in cataract ...
The Use of Molecular Modelling to Study Enzymic Action
(University of Canterbury. Department of Chemistry, 2011)
Molecular modelling has become widely used in chemistry and biology. The aim of this project is to use a range of molecular modelling techniques to study enzymic actions. This thesis consists of two parts. Part A of ...
Development of macrocyclic β-strand calpain cysteine protease inhibitors
(University of Canterbury. Chemistry, 2011)
The work in this thesis reports studies directed to developing a calpain cysteine protease inhibitor that could be of value in slowing cataract development in humans. The work focuses on the development of macrocyclic ...
Mechanism and Inhibition of Hypochlorous Acid-Mediated Cell Death in Human Monocyte-Derived Macrophages
(University of Canterbury. Biological Sciences, 2010)
Hypochlorous acid (HOCl) is a powerful oxidant produced by activated phagocytes at sites of inflammation to kill a wide range of pathogens. Yet, it may also damage and kill the neighbouring host cells. The abundance of ...