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Molecular Modelling for Enzyme Inhibition: A Search for a New Treatment for Cataract and New Antimicrobials and Herbicides
(University of Canterbury. Chemistry, 2010)
There have been several reports that cataract development results from unregulated Ca2+ mediated degradation of lens crystallins. The calpain isoform m-calpain, a cysteine protease, is known to be a major player in cataract ...
Mechanism and Inhibition of Hypochlorous Acid-Mediated Cell Death in Human Monocyte-Derived Macrophages
(University of Canterbury. Biological Sciences, 2010)
Hypochlorous acid (HOCl) is a powerful oxidant produced by activated phagocytes at sites of inflammation to kill a wide range of pathogens. Yet, it may also damage and kill the neighbouring host cells. The abundance of ...