Model-based identification and diagnosis of a porcine model of induced endotoxic shock with hemofiltration
Author
Starfinger, C.
Chase, J.G.
Hann, C.E.
Shaw, G.M.
Lambermont, B.
Ghuysen, A.
Kolh, P.
Dauby, P.C.
Desaive, T.
Date
2008Permanent Link
http://hdl.handle.net/10092/2243A previously validated cardiovascular system (CVS) model and parameter identification method for cardiac and circulatory disease states are extended and further validated in a porcine model (N = 6) of induced endotoxic shock with hemofiltration. Errors for the identified model are within 10% when the model is re-simulated and compared to the clinical data. All identified parameter trends over time in the experiments match clinically expected changes both individually and over the cohort. This work represents a further clinical validation of these model-based cardiovascular diagnosis and therapy guidance methods for use with monitoring endotoxic disease states.