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    Model-based identification and diagnosis of a porcine model of induced endotoxic shock with hemofiltration

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    Author
    Starfinger, C.
    Chase, J.G.
    Hann, C.E.
    Shaw, G.M.
    Lambermont, B.
    Ghuysen, A.
    Kolh, P.
    Dauby, P.C.
    Desaive, T.
    Date
    2008
    Permanent Link
    http://hdl.handle.net/10092/2243

    A previously validated cardiovascular system (CVS) model and parameter identification method for cardiac and circulatory disease states are extended and further validated in a porcine model (N = 6) of induced endotoxic shock with hemofiltration. Errors for the identified model are within 10% when the model is re-simulated and compared to the clinical data. All identified parameter trends over time in the experiments match clinically expected changes both individually and over the cohort. This work represents a further clinical validation of these model-based cardiovascular diagnosis and therapy guidance methods for use with monitoring endotoxic disease states.

    Subjects
    Cardiovascular system
     
    Cardiac model
     
    Parameter identification
     
    Integral method
     
    Endotoxin
     
    Hemofiltration
     
    Septic shock
     
    Fields of Research::290000 Engineering and Technology::291500 Biomedical Engineering
     
    Fields of Research::320000 Medical and Health Sciences::329900 Other Medical and Health Sciences::329902 Medical biotechnology
    Collections
    • Engineering: Journal Articles [933]
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