Determining the effects of insulin Detemir on endogenous secretion of insulin. (2019)
Type of ContentConference Contributions - Published
AuthorsKlenner, J.B., Van Noorden, B.A., Knopp, J.L., Holder Pearson, L.R., Hardy, A.R., Vergeer, S.L., Shaw, G.M., Chase, J.G.show all
Type 2 diabetes (T2D) is a long-term metabolic disorder. A pilot trial was designed to investigate the effects of the long acting insulin Detemir on endogenous insulin secretion, to assess use in early T2D care. Provesn metabolic system models are used to identify patient-specific insulin sensitivity and endogenous insulin secretion from clinical data. Post-cardiac surgery patients with early T2D or pre-diabetes based on HbA1c were given a bolus of insulin Detemir on one day, and none on the second day in hospital. Blood glucose, insulin, C-Peptide, and all nutrition given are recorded. Early results from N=3 patients show 0.8-1.0U/hour insulin Detemir doses have no apparent suppression of endogenous insulin secretion, but does help lower glucose levels. The results show the model captures glucose-insulin dynamics in pre-diabetic post-surgical patients, and insulin Detemir may be useful to support individuals with pre-diabetes in reducing blood glucose levels. Tests with higher doses, need to be carried out to verify these results over a greater range of patients.
CitationKlenner JB, Van Noorden BA, Knopp JL, Holder Pearson LR, Hardy AR, Vergeer SL, Shaw GM, Chase J (2019). Determining the effects of insulin Detemir on endogenous secretion of insulin.. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 2019. 2943-2946.
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ANZSRC Fields of Research09 - Engineering::0903 - Biomedical Engineering::090399 - Biomedical Engineering not elsewhere classified
11 - Medical and Health Sciences::1103 - Clinical Sciences::110306 - Endocrinology