Model-based Research in Mechanical Ventilation Treatment: The Development and Introduction to CURE trial (2019)
Mechanical ventilation (MV) is a primary support for respiratory failure patients. However, patient condition and response to treatment are heterogeneous and variable over time. Thus, general, one size fits all treatment approaches may not be suitable, and a more individualized approach could improve care and outcomes. Model-based therapy offers the opportunity to individualise MV to patient-specific needs at any given interval. It uses real-time identified patient-specific respiratory system model parameters to personalise and optimize care. This talk focuses on the journey from conceptual model-based MV ideas, through clinical proof of concept, and finally to a large randomized controlled trial.
CitationChiew YS, Tan CP, Chase JG (2019). Model-based Research in Mechanical Ventilation Treatment: The Development and Introduction to CURE trial. Berlin, Germany: 41st IEEE Engineering in Medicine and Biology Conference (IEEE EMBC). 23/07/2019-27/07/2019.
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ANZSRC Fields of Research32 - Biomedical and clinical sciences::3201 - Cardiovascular medicine and haematology::320103 - Respiratory diseases
40 - Engineering::4003 - Biomedical engineering::400308 - Medical devices
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Model-based PEEP titration versus standard practice in mechanical ventilation: A randomised controlled trial Kim KT; Morton S; Howe S; Chiew YS; Desaive T; Benyo B; Szlavecz A; Moeller K; Shaw, Geoff; Knopp, Jennifer; Docherty, Paul; Pretty, Christopher; Chase, Geoff (Springer Science and Business Media LLC, 2020)Background: Positive end-expiratory pressure (PEEP) at minimum respiratory elastance during mechanical ventilation (MV) in patients with acute respiratory distress syndrome (ARDS) may improve patient care and outcome. The ...
Chiew YS; Lambermont B; Morimont P; Shaw, Geoff; Desaive T; Chase, Geoff (Springer Science and Business Media LLC, 2020)
Holder Pearson L; Shaw, Geoff; Chase, Geoff (2020)