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    Drug-, dose- and sex-dependent effects of chronic fluoxetine, reboxetine and venlafaxine on open-field behavior and spatial memory in rats (2015)

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    Type of Content
    Journal Article
    UC Permalink
    http://hdl.handle.net/10092/17812
    
    Publisher's DOI/URI
    https://doi.org/10.1016/j.bbr.2014.12.023
    
    Publisher
    ELSEVIER SCIENCE BV
    ISSN
    0166-4328
    1872-7549
    Language
    English
    Collections
    • Science: Journal Articles [1099]
    Authors
    Gray VC
    Hughes RN
    show all
    Abstract

    © 2014 Elsevier B.V. In an effort to address the need to include both sexes in studies of effects of the SSRI fluoxetine, the NRI reboxetine and the SNRI venlafaxine on anxiety-related behavior and memory along with the use of chronic drug administration, male and female PVG/c rats were fed diets containing two doses of each drug for 21 days. The rats' anxiety level was then assessed in an open field. Short-term spatial memory for a brightness change in a Y maze was also measured. While there was little evidence of anxiolytic effects of any of the drugs, both fluoxetine and, to a l esser extent, venlafaxine appeared to be mainly anxiogenic in their action depending on both dose and sex. Reboxetine was relatively ineffective in this respect. Ability to locate the Y-maze arm that had changed (from white to black) seemed to be impaired for male (but not female) rats by both fluoxetine and venlafaxine and, to a much lesser extent, by reboxetine. Given the relative ineffectiveness of reboxetine in either test, it is possible that the effects of the other two drugs on both anxiety and memory were mainly due to their serotonin reuptake inhibiting properties. The differences that occurred between males and females in responsiveness to all three drugs supported the long-held view that both sexes should be investigated in studies of this sort, especially in view of reports of sex differences in effects of clinically prescribed antidepressants.

    Citation
    Gray VC, Hughes RN (2015). Drug-, dose- and sex-dependent effects of chronic fluoxetine, reboxetine and venlafaxine on open-field behavior and spatial memory in rats. Behavioural Brain Research. Volume 281, 15 March 2015, Pages 43-54
    This citation is automatically generated and may be unreliable. Use as a guide only.
    Keywords
    Science & Technology; Life Sciences & Biomedicine; Behavioral Sciences; Neurosciences; Neurosciences & Neurology; Fluoxetine; Reboxetine; Venlafaxine; Rats; Anxiety; Spatial memory; FORCED SWIMMING TEST; REUPTAKE INHIBITOR REBOXETINE; ANXIETY-RELATED BEHAVIOR; ELEVATED PLUS-MAZE; MAJOR DEPRESSION; DOUBLE-BLIND; ANTIDEPRESSANT DRUGS; HEALTHY-VOLUNTEERS; GENDER-DIFFERENCES; HOODED RATS
    ANZSRC Fields of Research
    32 - Biomedical and clinical sciences::3214 - Pharmacology and pharmaceutical sciences::321402 - Clinical pharmacology and therapeutics
    31 - Biological sciences::3109 - Zoology::310906 - Animal neurobiology
    17 - Psychology and Cognitive Sciences::1701 - Psychology::170101 - Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
    11 - Medical and Health Sciences::1109 - Neurosciences
    Rights
    Creative Commons Attribution Non-Commercial No Derivatives License

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