Derivative weighted active insulin control algorithms and trials
Close control of blood glucose levels significantly reduces vascular complications in diabetes. Heavy derivative controllers utilising the data density available from emerging biosensors are developed to provide tight, optimal control of elevated blood glucose levels. A two-compartment human model is developed for intravenous infusion from physiologically verified subcutaneous infusion models to enable a first of its kind, proof-of-concept clinical trial. Results show tight control with very similar performance to modelled behaviour and strong correlation between modelled insulin used versus the amounts used in clinical trials to validate the models and methods developed.