Anterior and lateral thalamic lesions in object-odour paired associate learning (2007)
Type of ContentTheses / Dissertations
Degree NameMaster of Science
PublisherUniversity of Canterbury. Biological Sciences
Diencephalic amnesia is thought to be the result of damage to a single thalamic structure that is responsible for the memory impairment. However, an alternative view is that different thalamic structures contribute to the memory impairment in subtly different ways. Paired-associate learning is one important measure of learning and memory that is highly sensitive to disruption in people with amnesia or dementia. The current study will investigate the influence of lesions to two thalamic subregions, the anterior thalamic nuclei (AT) and the lateral thalamic nuclei (LT) in an object-odour paired associate learning task. Each of these subregions has been suggested by the literature as critical for amnesia after thalamus injury. The current study does not involve a place/ space component. Both AT and LT lesions caused impairments in the object-odour paired associate task, but not in the simple discrimination tasks. The results of this study provide new evidence to suggest that the anterior thalamic region may be responsible for more than spatial memory processing. This result is inconsistent with those of Aggleton & Brown (1999) that consider the AT to be part of an 'extended hippocampal system'. The deficits observed from LT lesions in this study provide new insight into the lateral thalamic region's role in pattern processing.
KeywordsDiencephalic amnesia; memory; thalamus; anterior thalamic nuclei; lateral thalamic nuclei; paired-associate learning
RightsCopyright Rati Bell
Showing items related by title, author, creator and subject.
Gibb, Sheree Jacinda (University of Canterbury, 2005)A common view of diencephalic amnesia is that a single diencephalic structure is responsible for the memory impairment, but an alternative view is that different diencephalic structures contribute to the memory impairment ...
Lesions of the anteroventral or anteromedial thalamic nuclei impair working and reference memory in a twelve-arm radial maze Byatt, Graham (University of Canterbury, 1995)Controversy still surrounds the neural bases of diencephalic amnesia. Recent research in rats suggests that incidental damage to the anterior thalamus (AT) may be responsible for impairments following other experimental ...
Hamilton, Jennifer J. (University of Canterbury, 2020)The anterior thalamic nuclei (ATN) are a central node in a complex ‘hippocampal- diencephalic-cingulate’ memory system. The integrity of the anterior thalamic nuclei is linked with severe amnesia in the Korsakoff’s syndrome, ...