Interstitial insulin kinetic parameters for a 2-compartment insulin model with saturable clearance

Type of content
Journal Article
Thesis discipline
Degree name
Publisher
ELSEVIER IRELAND LTD
Journal Title
Journal ISSN
Volume Title
Language
English
Date
2014
Authors
Pretty CG
Le Compte A
Penning S
Fisk L
Shaw, Geoff
Desaive T
Chase, Geoff
Abstract

Glucose-insulin system models are commonly used for identifying insulin sensitivity. With physiological, 2-compartment insulin kinetics models, accurate kinetic parameter values are required for reliable estimates of insulin sensitivity. This study uses data from 6 published microdialysis studies to determine the most appropriate parameter values for the transcapillary diffusion rate (nI) and cellular insulin clearance rate (nC).The 6 studies (12 data sets) used microdialysis techniques to simultaneously obtain interstitial and plasma insulin concentrations. The reported plasma insulin concentrations were used as input and interstitial insulin concentrations were simulated with the interstitial insulin kinetics sub-model. These simulated results were then compared to the reported interstitial measurements and the most appropriate set of parameter values was determined across the 12 data sets by combining the results. Interstitial insulin kinetic parameters values nI=nC=0.0060min-1 were shown to be the most appropriate. These parameter values are associated with an effective, interstitial insulin half-life, t1/2=58min, within the range of 25-130min reported by others. © 2014 Elsevier Ireland Ltd.

Description
Citation
Pretty CG, Le Compte A, Penning S, Fisk L, Shaw GM, Desaive T, Chase JG (2014). Interstitial insulin kinetic parameters for a 2-compartment insulin model with saturable clearance. Computer Methods and Programs in Biomedicine. 114(3). E39-E45.
Keywords
Biomedical system modelling, Simulation and visualisation, Control of physiological and clinical variables
Ngā upoko tukutuku/Māori subject headings
ANZSRC fields of research
Field of Research::09 - Engineering::0903 - Biomedical Engineering
Fields of Research::32 - Biomedical and clinical sciences::3202 - Clinical sciences::320208 - Endocrinology
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