Nitric oxide signalling in the basolateral complex of the amygdala: an extension of NMDA receptor activation during Pavlovian fear conditioning and expression (2006)
Type of ContentTheses / Dissertations
Degree NameMaster of Science
PublisherUniversity of Canterbury. Psychology
N-methyl-D-asparate (NMDA) receptors located within the basolateral complex of the amygdala are required for the consolidation and expression of Pavlovian conditioned fear. The events downstream of receptor activation that mediate these processes are not well defined. An intermediate step that may be of significance is the synthesis of the gas nitric oxide (NO). Nitric oxide is synthesised as a result of NMDA receptor activation and acts as an unconventional neurotransmitter freely diffusing across cell membranes interacting with its targets in a non-synaptic manner. The targets of NO include cellular components that play significant roles during the consolidation of conditioned fear and the neurotransmission associated with its expression. This implies that NO may be an important intermediary of NMDA receptor activation and both these processes. The current study sought to examine this possibility using fear potentiated startle to examine the expression of learned fear. Three experiments were conducted, fifty rats received intra-BSC microinfusions of the global nitric oxide synthase inhibitor L-NAME either prior to fear conditioning, fear testing, or examination of the shock sensitization of the acoustic startle affect. The results indicated that NO was indeed required for both the consolidation and expression of learned fear, whereas it was not required for shock enhanced startle responding. This study provides new information about the sub-cellular basis of conditioned fear, and highlights the pivotal role played by NO in processes associated with conditioned fear.
KeywordsNitric oxide; Pavlovian Fear conditioning; Fear expression; Shock sensitisation of the acoustic startle; Amygdala
RightsCopyright Kathie Overeem
Showing items related by title, author, creator and subject.
Retrograde signalling within fear neurocircuitry: Nitric oxide signalling from the lateral nucleus of the amygdala regulates thalamic EGR-1 mediated alterations of presynaptic protein levels during auditory fear conditioning Overeem, Kathie (University of Canterbury. Psychology, 2009)Previous research has shown that nitric oxide signalling in the lateral nucleus of the amygdala is required for the consolidation of Pavlovian conditioned fear. Given the evidence that nitric oxide can act as a retrograde ...
The involvement of amygdala neurons and amygdaloid dopaminergic and glutamatergic receptors in the acquisition and reinstatement of fear-potentiated startle in rats. Greba, Quentin Matthew Luke (University of Canterbury. Psychology, 2005)The basolateral amygdala (BLA) contains NMDA, AMPA, and dopamine (DA) D1 and D2 receptors and neurobiochemical events within the amygdala mediate conditioned-fear-learning (CFL) and fear expression. Long-term potentiation ...
The Influence of Boron on the Emission of Sodium during Black Liquor Combustion under Oxidative Conditions Saw, W.L.; Forssén, M.; Hupa, M.; Nathan, G.J.; Ashman, P.J. (University of Canterbury. Chemical and Process Engineering, 2009)The addition of boron to black liquor has the potential to reduce fume formation in a Kraft recovery boiler. Two Kraft black liquors, with and without boron, were analysed. Single 10 mg droplets were introduced into a ...