Biochemical Sensing Assays based on Coalescence-induced Self-propulsion Digital Microfluidics (2013)
Type of ContentConference Contributions - Published
PublisherUniversity of Canterbury. Electrical and Computer Engineering
University of Canterbury. Mechanical Engineering
University of Canterbury. Biomolecular Interaction Centre
AuthorsNock, V., Muller, Y., Sellier, M., Verdier, C.show all
This work reports on coalescence-induced selfpropulsion as a driving mechanism to actuate microfluidic droplet assays. We demonstrate multi-droplet translation and assay-type sensing on a digital microfluidics platform by use of surface tension gradients alone. These gradients arise during the coalescence of two droplets of liquid having different compositions and therefore surface tensions. We demonstrate a chemiluminescence blood-detection reaction based on the mixing of two carrier droplets containing solutions of synthetic blood and luminol sensor solution. Presence of iron in the blood solution is recorded using digital imaging and analyzed via offline image processing. The results demonstrate the capability of the propulsion mechanism to propel droplets over several millimeters, thus enabling one to design a new family of chip-based biochemical sensor assays.
CitationNock, V., Muller, Y., Sellier, M., Verdier, C. (2013) Biochemical Sensing Assays based on Coalescence-induced Self-propulsion Digital Microfluidics. Wellington, New Zealand: 7th International Conference on Sensing Technology (ICST 2013), 3-5 Dec 2013. in press.
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KeywordsMicrofluidics; sensor assay; chemiluminescence; luminol; image processing
ANZSRC Fields of Research09 - Engineering::0903 - Biomedical Engineering
09 - Engineering::0906 - Electrical and Electronic Engineering
09 - Engineering::0903 - Biomedical Engineering::090302 - Biomechanical Engineering